Loperamide hydrochloride (HCl) has been used in inflammatory pain experiments and to assess the functionality of proteins.[1] 54
Biochem/physiol Actions
Loperamide hydrochloride (HCl) is a non-selective Ca2+ channel blocker. At nanomolar concentrations, it binds to μ-opioid receptors. Loperamide HCl does not cross the blood-brain barrier.
Features and Benefits
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Preparation Note
Slightly soluble in water and dilute acids, freely soluble in methanol and in chloroform, soluble in ethanol (95%).
The effects of the antidiarrheal agent loperamide on high-voltage-activated (HVA) calcium channel activity and excitatory amino acid-evoked responses in two preparations of cultured hippocampal pyramidal neurons were examined. In rat hippocampal neurons loaded with the calcium-sensitive dye fura-2, rises in
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