D8428
Decorin from bovine articular cartilage
salt-free, lyophilized powder
Synonym(s):
Decorin protein
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About This Item
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biological source
bovine articular cartilage
Quality Level
form
salt-free, lyophilized powder
mol wt
~100 kDa
packaging
glass bottle of 0.5 mg
technique(s)
cell culture | mammalian: suitable
solubility
PBS: ≥2.00 mg/mL, clear, colorless to yellow
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... DCN(280760)
General description
Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.
Application
Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.
Biochem/physiol Actions
Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.
Other Notes
Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Seda Duran G Ler et al.
Indian journal of ophthalmology, 69(2), 369-373 (2021-01-20)
The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen T M, et al.
The Journal of Biological Chemistry, 287(28), 23332-23345 (2012)
Caroline Pehrson et al.
Vaccine, 35(4), 610-618 (2016-12-26)
Malaria in pregnancy is associated with significant morbidity in pregnant women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express VAR2CSA that mediates binding to chondroitin sulphate A (CSA) in the placenta. Two VAR2CSA-based vaccines for placental malaria are in
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
Reese S P, et al.
Matrix Biology, 32(7-8), 414-423 (2013)
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.
Khunrae P, et al.
Journal of Molecular Biology, 397(3), 826-834 (2010)
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