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Key Documents

04473

Sigma-Aldrich

2,4-Pyridinedicarboxylic acid

≥98.0%

Synonym(s):

Lutidinic acid

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About This Item

Empirical Formula (Hill Notation):
C7H5NO4
CAS Number:
Molecular Weight:
167.12
Beilstein:
131631
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25

Quality Level

Assay

≥98.0%
98.0-102.0% (T)

SMILES string

OC(=O)c1ccnc(c1)C(O)=O

InChI

1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

MJIVRKPEXXHNJT-UHFFFAOYSA-N

Application

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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C K Derian et al.
The Journal of biological chemistry, 264(12), 6615-6618 (1989-04-25)
While a role has been ascribed to the gamma-carboxyglutamate (Gla) residues in vitamin K-dependent coagulation proteins and the enzyme catalyzing this posttranslational modification has been identified and partially characterized, both the functional significance of a second posttranslationally synthesized amino acid
John R G Sander et al.
Journal of pharmaceutical sciences, 99(9), 3676-3683 (2010-06-25)
We report on a co-crystal of acetaminophen (APAP) and 2,4-pyridinedicarboxylic acid (PDA). The co-crystal was discovered by screening using the solution-mediated phase transformation (SMPT) technique. Despite the bulk solids of each component being white in color, the new co-crystal phase
Guo-liang Gu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(1), 209-214 (2008-02-19)
Two novel ligands containing two pyridine-2,6-dicarboxylic acid conjugative units, 4-(2-(2,6-dicarbox-ypyridin-4-yl)vinyl)pyridine-2,6-dicarboxylic acid (L1) and 4-(4-(2-(2,6-dicarboxypyridin-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylic acid (L2) and their complexes with Tb(III) have been synthesized and characterized by elemental analysis, IR spectra and NMR. The ligand synthetic route was optimized and
Michael Raghunath et al.
Biochemical and biophysical research communications, 378(4), 766-771 (2008-12-11)
The rapid vascularisation of biomaterials and engineered tissue after implantation is a current unmet need. To this end, we explored the pharmacological option of inducing neovascularisation using compounds that inhibit hypoxia-induced factor-1alpha prolyl hydroxylase. This stabilises hypoxia inducible factor-1alpha and
H M Rowe et al.
Applied spectroscopy, 57(5), 532-537 (2003-12-09)
An adaptation of square-wave gated phase-modulation (GPM) fluorimetry allows for self-referenced intensity measurements without the complexity of dual excitation or dual emission wavelengths. This AC technique utilizes square-wave excitation, gated detection, a reference emitter, and a sensor molecule. The theory

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