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Key Documents

ABN131

Sigma-Aldrich

Anti-GABA Antibody

from rabbit, purified by affinity chromatography

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

species reactivity (predicted by homology)

all

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)

shipped in

wet ice

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MABF424MABF423MABF580
Gene Information

human ... CD44(960)

Gene Information

human ... CD44(960)
mouse ... Cd44(12505)

Gene Information

human ... CD44(960)
mouse ... Cd44(12505)

Gene Information

human ... CD44(960)
mouse ... Cd44(12505)

species reactivity

mouse

species reactivity

human, mouse

species reactivity

human, mouse

species reactivity

mouse, human

biological source

rat

biological source

rat

biological source

rat

biological source

rat

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

Neurotransmitters can be defined as chemical substances that are released by the presynaptic neuron before being bound by receptors on the postsynaptic cell surface. It has been well established that the nervous system utilizes neurotransmitters for cell signaling. Neurotransmitters can be divided into two groups; low molecular weight transmitter molecules such as biogenic amines, purines, or amino acids, and bioactive peptides, of which more than 50 members have been identified in the mammalian central nervous system. Many low molecular weight neurotransmitters are produced within the axon terminal from common cellular metabolites and packaged into synaptic vesicles. The transport and delivery of vesicles containing neurotransmitter is a highly regulated and complex process. GABA (g-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system that is involved in the pathogenesis of certain neurological and psychiatric disorders. GABA is produced from glutamic acid in a reaction catalyzed by glutamic acid decarboxylase. GABA interacts with the GABAA and GABAB receptors, which are widely distributed throughout the nervous system and in a variety of cell types. The immunolocalization, neuronal distribution, and vesicular compartmentalization of neurotransmitter molecules and their precursors are important for understanding the modulation, regulation, and function of neurotransmitters in the nervous system.

Application

Anti-GABA Antibody is a highly specific rabbit polyclonal antibody, that targets GABA & has been tested in IHC (Paraffin) & Enzyme Immunoassay (ELISA).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABA in rat brain tissue (Note: Non-specific staining may be observed in vascular tissues.).

ELISA Analysis: A representative lot from an independent laboratory detected GABA in a competitive ELISA.

Quality

Evaluated by Immunohistochemistry (Paraffin) in Rat brain tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected GABA in Rat brain tissue sections.

Linkage

Replaces: AB131

Analysis Note

Control
Rat hypothalamus tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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