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D64600

Sigma-Aldrich

5,7-Dichloro-8-quinolinol

99%

Synonym(s):

5,7-Dichloro-8-hydroxyquinoline, Chloroxine

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About This Item

Empirical Formula (Hill Notation):
C9H5Cl2NO
CAS Number:
773-76-2
Molecular Weight:
214.05
EC Number:
212-258-3
MDL number:
MFCD00006786
UNSPSC Code:
12352100
PubChem Substance ID:
24894028
NACRES:
NA.22

Quality Level

100

Assay

99%

form

powder

mp

178-180 °C (lit.)

SMILES string

Oc1c(Cl)cc(Cl)c2cccnc12

InChI

1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChI key

WDFKMLRRRCGAKS-UHFFFAOYSA-N

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Related Categories

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H318,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo.
M J Schaeken et al.
Caries research, 18(5), 440-446 (1984-01-01)
Miriam Aide Castillo Rodríguez et al.
Journal of pharmaceutical and biomedical analysis, 166, 113-118 (2019-01-15)
A new, rapid, simple and specific method to determine 5-chloro 8-hydroxyquinoline (5-HQ) and 5,7-dichloro 8-hydroxyquinoline (5,7-HQ) stability in swine feed was optimized and validated. A system consisting of an ACQUITY UPLC BEH C18 column (1.7 μm, 2.1 mm × 100 mm), a mobile phase of
Luying Xun et al.
The Journal of biological chemistry, 279(8), 6696-6700 (2003-12-10)
Ralstonia eutropha JMP134 2,4,6-trichlorophenol (2,4,6-TCP) 4-monooxygenase catalyzes sequential dechlorinations of 2,4,6-TCP to 6-chlorohydroxyquinol. Although 2,6-dichlorohydroxyquinol is a logical metabolic intermediate, the enzyme hardly uses it as a substrate, implying it may not be a true intermediate. Evidence is provided to
[Clinical evaluation on the usefulness of 5,7-dichloro-8-hydroxyquinoline (chloroxine) in association with betamethasone 17-benzoate in the topical treatment of infected cortisone-sensitive dermopathies].
M Negosanti et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 120(2), XVII-XXIII (1985-03-01)
Tomas Kudera et al.
Pharmaceuticals (Basel, Switzerland), 13(9) (2020-09-10)
A desirable attribute of novel antimicrobial agents for bacterial diarrhea is decreased toxicity toward host intestinal microbiota. In addition, gut dysbiosis is associated with an increased risk of developing intestinal cancer. In this study, the selective growth-inhibitory activities of ten
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