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Key Documents

A76109

Sigma-Aldrich

3-Amino-1-propanesulfonic acid

97%

Synonym(s):

3APS, Homotaurine, Tramiprosate

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About This Item

Linear Formula:
H2N(CH2)3SO3H
CAS Number:
Molecular Weight:
139.17
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

form

solid

mp

293 °C (dec.) (lit.)

SMILES string

NCCCS(O)(=O)=O

InChI

1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChI key

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

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Application

Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P S Aisen et al.
Neurology, 67(10), 1757-1763 (2006-11-04)
As a potential disease-modifying treatment for Alzheimer disease (AD), 3-amino-1-propanesulfonic acid (3APS) is a compound that binds to amyloid beta (Abeta), a toxic protein known to aggregate, leading to amyloid plaque deposition in the brain. We assessed the safety, tolerability
Chem. Abstr., 86, 25685r-25685r (1977)
D A Brown et al.
British journal of pharmacology, 59(2), 373-378 (1977-02-01)
1 The effect of inhibiting the transport of gamma-aminobutyric acid (GABA) by neuroglial cells on the depolarizing action of exogenous amino acids on isolated superior cervical ganglia of the rat was studied. 1 Transport (measured by uptake of [3H]-GABA) was
D Saumier et al.
The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the
A comparison of the effects of GABA, 3-aminopropanesulphonic acid and imidazoleacetic acid on the frog spinal cord.
A Nistri et al.
Neuropharmacology, 17(1), 13-19 (1978-01-01)

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