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805092

Sigma-Aldrich

PLGA nanoparticles

100 nm average diameter

Synonym(s):

Degradex® PLGA, poly(D,L-lactide-co-glycolide)

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About This Item

Linear Formula:
HO(C3H4O2)x(C2H2O2)yH
UNSPSC Code:
12162002
NACRES:
NA.23
Pricing and availability is not currently available.

form

powder

Quality Level

100

average diameter

100 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.
The particle size of the PLGA nanoparticles are closely dependent on both the nature and concentration of the stabilizer and polymer.[1][2]

Application

Plain PLGA particles can be used for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.A study reports the use of PLGA nanoparticles as estrogen carriers. The carrier-drug system was prepared by emulsification-diffusion method.[1][2]

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX0810
MKCW1688
MKCT2852
MKCT9440
MKCR7346

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Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
Kwon HY, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 182(1-3), 123-130 (2001)
The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers
Qaddoumi MG, et al.
Pharmaceut. Res., 21(4), 641-648 null

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Need more info on how to use the particles: How long are the PLGA nanoparticles stable for once reconstituted in water/PBS? Is 20mg/ml a good concentration to resuspend at? Presumably they should be stored at 4°C instead of refrozen once reconstituted?

    1 answer

    1. The stability of the PLGA nanoparticles in the solution is not determined. However, various sources state that suspensions may be stable for greater than 2 weeks in aqueous buffers when stored at 4°C. See the link below for preparation and surface conjugation instructions. Allow the product to reach room temperature before suspending it in water or buffer. Suspensions may require vertexing or sonication:
      https://www.sigmaaldrich.com/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/egradex-microspheres-nanoparticles

      It may be helpful to review the additional publications below:
      https://pubs.acs.org/doi/pdf/10.1021/acs.macromol.0c00110

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