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441511

Sigma-Aldrich

N-Acetyl-L-leucine

99%, for peptide synthesis, ReagentPlus®

Synonym(s):

N-Acetyl-L-(-)-leucine, Acetylleucine

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NHCOCH3)CO2H
CAS Number:
1188-21-2
Molecular Weight:
173.21
Beilstein:
1724849
EC Number:
214-706-3
MDL number:
MFCD00065131
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24867665
NACRES:
NA.22

product name

N-Acetyl-L-leucine, ReagentPlus®, 99%

product line

ReagentPlus®

Assay

99%

form

solid

optical activity

[α]25/D −23±3°, c = 2 in ethanol

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

mp

187-190 °C (lit.)

application(s)

peptide synthesis

functional group

amine
carboxylic acid

SMILES string

CC(C)C[C@H](NC(C)=O)C(O)=O

InChI

1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

InChI key

WXNXCEHXYPACJF-ZETCQYMHSA-N

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Nathaniel J Traaseth et al.
The journal of physical chemistry. B, 114(43), 13872-13880 (2010-10-13)
NMR spin diffusion experiments have the potential to provide both resonance assignment and internuclear distances for protein structure determination in oriented solid-state NMR. In this paper, we compared the efficiencies of three spin diffusion experiments: proton-driven spin diffusion (PDSD), cross-relaxation-driven
T Gopinath et al.
Journal of the American Chemical Society, 132(15), 5357-5363 (2010-03-30)
We present new sensitivity enhanced schemes for heteronuclear correlation spectroscopy (HETCOR) in solid-state NMR of oriented systems. These schemes will enhance the sensitivity of the HETCOR by 40% for the two-dimensional experiments (SE-HETCOR) and up to 180% for the 3D
Chin H Wu et al.
The Journal of chemical physics, 128(5), 052312-052312 (2008-02-13)
The acquisition and analysis of high resolution one- and two-dimensional solid-state nuclear magnetic resonance (NMR) spectra without chemical shift frequencies are described. Many variations of shiftless NMR spectroscopy are feasible. A two-dimensional experiment that correlates the dipole-dipole and dipole-dipole couplings
P Benard et al.
European journal of drug metabolism and pharmacokinetics, 26(1-2), 71-76 (2001-09-14)
Acetyl-DL-leucine [2-14C]: Tanganil a antivertigal drug has been injected intravenously in two macaca monkeys which have been sacrificed 2 and 5 minutes later. Radioactivity distribution has been studied by autoradiography in the brain. An important uptake of radioactivity is localized
T Suzuki et al.
FEBS letters, 381(3), 195-198 (1996-03-04)
To investigate the function of tRNAs or any other aminoacylable RNAs in vivo, it is important to be able to estimate the amounts and species of aminoacylated RNAs in living cells. We have developed a method of analyzing amino acids
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