Saltar al contenido
Merck
  • Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis - Tampere Vascular Study.

Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis - Tampere Vascular Study.

Scientific reports (2018-10-12)
Petteri Rinne, Leo-Pekka Lyytikäinen, Emma Raitoharju, James J Kadiri, Ivana Kholova, Mika Kähönen, Terho Lehtimäki, Niku Oksala
RESUMEN

α-melanocyte-stimulating hormone (α-MSH) is processed from pro-opiomelanocortin (POMC) and mediates anti-inflammatory actions in leukocytes. α-MSH also promotes macrophage reverse cholesterol transport by inducing ATP-binding cassette transporters ABCA1 and ABCG1. Here we investigated the regulation of POMC and α-MSH expression in atherosclerosis. First, transcript levels of POMC and its processing enzymes were analyzed in human arterial plaques (n = 68) and non-atherosclerotic controls (n = 24) as well as in whole blood samples from coronary artery disease patients (n = 55) and controls (n = 45) by microarray. POMC expression was increased in femoral plaques compared to control samples as well as in unstable advanced plaques. α-MSH-producing enzyme, carboxypeptidase E, was down-regulated, whereas prolylcarboxypeptidase, an enzyme inactivating α-MSH, was up-regulated in unstable plaques compared to stable plaques, suggesting a possible reduction in intraplaque α-MSH levels. Second, immunohistochemical analyses revealed the presence of α-MSH in atherosclerotic plaques and its localization in macrophages and other cell types. Lastly, supporting the role of α-MSH in reverse cholesterol transport, POMC expression correlated with ABCA1 and ABCG1 in human plaque and whole blood samples. In conclusion, α-MSH is expressed in atherosclerotic plaques and its processing enzymes associate with plaque stability, suggesting that measures to enhance the local bioavailability of α-MSH might protect against atherosclerosis.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Anti-PRCP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Número de referencia del producto (SKU)Referencia (SKU) del distribuidorTamaño de envaseDisponibilidadPrecio
EN300-1879623-50MG50 mg
Se envía en 14 días desde el socio de Aldrich
EUR 362.20
EN300-1879623-100MG100 mg
Se envía en 14 días desde el socio de Aldrich
EUR 518.20
EN300-1879623-250MG250 mg
Se envía en 14 días desde el socio de Aldrich
EUR 719.70
EN300-1879623-500MG500 mg
Se envía en 14 días desde el socio de Aldrich
EUR 1,107.10
EN300-1879623-1G1 g
Se envía en 14 días desde el socio de Aldrich
EUR 1,406.10
EN300-1879623-2.5G2.5 g
Se envía en 14 días desde el socio de Aldrich
EUR 2,713.90
EN300-1879623-5G5 g
Se envía en 14 días desde el socio de Aldrich
EUR 3,993.10

Para encargar productos, Contacto su distribuidor local.