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Merck

1082708

USP

2,6-Di-tert-butyl-4-methylphenol

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Fórmula lineal:
[(CH3)3C]2C6H2(CH3)OH
Número de CAS:
Peso molecular:
220.35
Beilstein/REAXYS Number:
1911640
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

API family

butylated hydroxytoluene

autoignition temp.

878 °F

manufacturer/tradename

USP

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Butylated hydroxytoluene USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Dutasteride and Tamsulosin Hydrochloride Capsules

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Butylated Hydroxytoluene
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(6), 5652-5652 (2021)
Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.
A L Branen
Journal of the American Oil Chemists' Society, 52(2), 59-63 (1975-02-01)
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
A M Malkinson
Environmental mutagenesis, 5(3), 353-362 (1983-01-01)
Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the
Krzysztof Kurek et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1074-1083 (2013-10-11)
Nonalcoholic fatty liver disease (NAFLD) is an insulin resistance-related hepatic disorder which can transform to cirrhosis. Insulin resistance deregulates hepatic lipid metabolism, leading to accumulation of cytotoxic lipids including ceramide and diacylglycerols. Myriocin, obtained from fungi traditionally used in Chinese

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