1008501

Acetylcholine chloride

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: ACh
• Fórmula lineal: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• Número CAS: 60-31-1
• Peso molecular: 181.66
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329748884
• MDL number: MFCD00011698
• Beilstein/REAXYS Number: 3571875

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: acetylcholine
• manufacturer/tradename: USP
• mp: 146-150 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• Gene Information: human ... CHRM3(1131)

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetylcholine chloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

• Acetylcholine Chloride for Ophthalmic Solution
• Methacholine Chloride

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable