T5443

Tyrphostin AG 825

≥92.5%

• Sinónimos: 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• Fórmula empírica (notación de Hill): C₁₉H₁₅N₃O₃S₂
• Número de CAS: 149092-50-2
• Peso molecular: 397.47
• Número MDL: MFCD01074971
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329826823
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥92.5%
• Formulario: powder
• solubilidad: DMSO: soluble; methanol: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• Clave InChI: KXDONFLNGBQLTN-WUXMJOGZSA-N

Descripción

Aplicación

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

Acciones bioquímicas o fisiológicas

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

Características y beneficios

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Nota de preparación

Tyrphostin AG 825 is soluble in DMSO and methanol.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)