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Key Documents

SRP0570

Sigma-Aldrich

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

Sinónimos:

5′- nucleotidase, Ecto-5′-nucleotidase

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

recombinant

expressed in HEK 293 cells

form

frozen liquid

mol wt

58.6 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NT5E(4907)

General description

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Application

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Biochem/physiol Actions

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Physical form

Aqueous solution

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Amanda de Fraga Dias et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 162, 105823-105823 (2021-03-31)
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults and the current treatments only have a modest effect on patient survival. Recent studies show that bozepinib (BZP), a purine derivative, has potential applications in cancer treatment. The
Targeting CD73 to augment cancer immunotherapy
Meejeon Roh, et al.
Current Opinion in Psychiatry, 53, 66-76 (2020)

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