SML3120

LY272015

≥98% (HPLC)

• Sinónimos: 1-[(3,4-Dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole monohydrochloride, 1H-Pyrido[3,4-b]indole, 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-, hydrochloride (1:1), LY 272015, LY-272015
• Fórmula empírica (notación de Hill): C₂₁H₂₄N₂O₂ · HCl
• Número de CAS: 172895-15-7
• Peso molecular: 372.89
• Número MDL: MFCD00933882
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: CC1=CC(C2=C(C(NCC2)CC(C=C3OC)=CC=C3OC)N4)=C4C=C1.Cl
• InChI: 1S/C21H24N2O2.ClH/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3;/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3;1H
• Clave InChI: BKAZOTIBKRWLQA-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

High-affinity, 5-HT2B subtype-selective serotonin receptor antagonist with in vitro and in vivo efficacy.

LY272015 is a high-affinity, 5-HT2B subtype-selective serotonin receptor antagonist (5-HT2B -log KB = 9.86, 5-HT2A/5-HT2C -log Ki = 7.65/7.92) that exhibits antihypertensive efficacy in deoxycorticosterone acetate (DOCA)-salt-hypertensive rats in vivo (1, 3 mg/kg iv; 1x/wk for 4 wks). LY272015 inhibits mitral valve interstitial cell (MVIC) activation by 5HT in cultures (100 nM LY, 10 nM or 1 μM 5HT; canine MVIC) and ex vivo (100 μM LY, 10 μM 5HT; human MV), as well as mitigates angiotensin II infusion-provoked MV remodeling in mice in vivo (3 mg/kg via infusion by osmotic pumps 2x/wk).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable