SML2525

Tafluprost

≥98% (HPLC)

• Sinónimos: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168
• Fórmula empírica (notación de Hill): C₂₅H₃₄F₂O₅
• Número CAS: 209860-87-7
• Peso molecular: 452.53
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD08062150
• Assay: ≥98% (HPLC)
• Form: oil

Propiedades

• assay: ≥98% (HPLC)
• form: oil
• optical activity: [α]/D +20 to +25°, c = 1 in chloroform-d
• color: colorless to yellow
• storage temp.: −20°C
• SMILES string: FC(F)(COc2ccccc2)\C=C\C1C(CC(C1C\C=C\CCCC(=O)OC(C)C)O)O
• InChI: 1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+
• InChI key: WSNODXPBBALQOF-ZHDUIJGQSA-N

Descripción

Biochem/physiol Actions

Prostaglandin F2α agonist; Antiglaucoma agent

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Warning
• Códigos de peligro: H361d
• Indicaciones de precaución: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable