SML1469

Ulipristal acetate

≥98% (HPLC)

• Sinónimos: (11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione, CDB-2914
• Fórmula empírica (notación de Hill): C₃₀H₃₇NO₄
• Número de CAS: 126784-99-4
• Peso molecular: 475.62
• Número MDL: MFCD00899035
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329825903
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D +165 to +185°, c = 1 in dichloromethane
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(C)[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C)C=C5)C[C@@]21C)=O
• InChI: 1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1
• Clave InChI: OOLLAFOLCSJHRE-ZHAKMVSLSA-N
• Información sobre el gen: human ... PGR(5241)

Descripción

Acciones bioquímicas o fisiológicas

Ulipristal acetate is a selective progesterone receptor modulator (SPRM) with tissue-selective partial antagonist activity. It has clinical use both as an emergency contraceptive and as a treatment for uterine fibroids. Ulipristal acetate acts as a partial antagonist on the hypothalamic–pituitary–ovarian axis to inhibit or delay ovulation without affecting human embryo implantation. As a progesterone antagonist, Ulipristal acetate selectively suppresses neo-vascularization, cell proliferation, and survival in uterine fibroid cells, but not in normal myometrial cells.

Ulipristal acetate is a selective progesterone receptor modulator (SPRM); contraceptive and treatment for fibroid tumors.

Ulipristal acetate is known to reduce uncontrolled bleeding due to post uterine fibroid surgery.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H361fd
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable