SML1414

Liproxstatin-1

>98% (HPLC), powder, ferroptosis inhibitor

• Sinónimos: N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine, N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4′-piperidine]-2-amine
• Fórmula empírica (notación de Hill): C₁₉H₂₁ClN₄
• Número de CAS: 950455-15-9
• Peso molecular: 340.85
• Número MDL: MFCD14948691
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825860
• NACRES: NA.77

Propiedades

• Nombre del producto: Liproxstatin-1, >98% (HPLC)
• Nivel de calidad: 100
• Ensayo: >98% (HPLC)
• Formulario: powder
• color: white to light brown
• solubilidad: DMSO: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
• InChI: 1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
• Clave InChI: YAFQFNOUYXZVPZ-UHFFFAOYSA-N

Descripción

Aplicación

Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.

Acciones bioquímicas o fisiológicas

Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Liproxstatin-1 is a potent inhibitor of ferroptosis.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable