SML0120

Perhexiline maleate salt

≥98% (HPLC)

• Sinónimos: 2-(2,2-Dicyclohexylethyl)piperidine
• Fórmula empírica (notación de Hill): C₁₉H₃₅N · C₄H₄O₄
• Número de CAS: 6724-53-4
• Peso molecular: 393.56
• Número CE: 229-775-5
• Número MDL: MFCD00057329
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825171
• NACRES: NA.25

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to tan
• solubilidad: DMSO: ≥5 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
• InChI: 1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
• Clave InChI: JDZOTSLZMQDFLG-BTJKTKAUSA-N
• Información sobre el gen: human ... CPT1B(1375) , CPT2(1376) , MTOR(2475)

Descripción

Descripción general

Perhexiline maleate regulates coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with papilledema and proximal myopathy.

Aplicación

Perhexiline maleate salt has been used as a stock for worm lifespan assay. It has also been used to block fatty acid oxidation.

Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′ adenosine monophosphate-activated protein kinase (AMPK) activator and in worm lifespan assay.

Acciones bioquímicas o fisiológicas

Anti-anginal metabolic modulator; carnitine palmitoyltransferase inhibitor

Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable