SMB00912
Pseudouridine
≥98% (HPLC)
Sinónimos:
Pseudouridine, β-Pseudouridine, ψ-Uridine, 5-(β-D-Ribofuranosyl)uracil
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About This Item
Fórmula empírica (notación de Hill):
C9H12N2O6
Número de CAS:
Peso molecular:
244.20
Código UNSPSC:
41106305
NACRES:
NA.79
Productos recomendados
origen biológico
synthetic (chemical)
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
mol peso
244.2
color
white to off-white
mp
222 °C ((432 °F ))
solubilidad
water: soluble
temp. de almacenamiento
2-8°C
cadena SMILES
[nH]1[c]([nH]cc([c]1=O)[C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=O
InChI
1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
Clave InChI
PTJWIQPHWPFNBW-GBNDHIKLSA-N
Descripción general
Pseudouridine (Ψ) stands as an isomer of the nucleoside uridine, featuring a carbon-carbon bond instead of the typical nitrogen-carbon glycosidic bond connecting uracil. It represents the most prevalent among the myriad modified nucleosides within RNA, with a presence spanning various species and RNA classes. The enzymatic action of Ψ synthases induces post-transcriptional isomerization of specific uridine residues, a process known as pseudouridylation. This modification, particularly in rRNA and tRNA, plays a vital role in fine-tuning and stabilizing regional structures, contributing to mRNA decoding, ribosome assembly, processing, and translation functions. Moreover, β-pseudouridine, identified in tRNAs across bacteria, archaea, and eukaryotes, has demonstrated potential in reducing radiation-induced chromosome aberrations in human lymphocytes. Its utility as a cancer and proliferation biomarker positions it as a valuable asset in metabolomics and biochemical research.
Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a β-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases, which post-transcriptionally isomerize specific uridine residues in RNA.
Aplicación
Pseudouridine is a versatile compound and a biomarker that finds application in metabolomics and biochemical research.
Características y beneficios
- High-purity compound suitable for a wide variety of research applications
Otras notas
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Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Journal of molecular medicine (Berlin, Germany), 98(12), 1767-1779 (2020-11-05)
Advanced non-viral gene delivery experiments often require co-delivery of multiple nucleic acids. Therefore, the availability of reliable and robust co-transfection methods and defined selection criteria for their use in, e.g., expression of multimeric proteins or mixed RNA/DNA delivery is of
Sang-Hoon Kim et al.
Nucleic acids research, 49(1), 491-503 (2020-12-09)
RNA modifications can regulate the stability of RNAs, mRNA-protein interactions, and translation efficiency. Pseudouridine is a prevalent RNA modification, and its metabolic fate after RNA turnover was recently characterized in eukaryotes, in the plant Arabidopsis thaliana. Here, we present structural
Glynis Klinke et al.
Journal of inherited metabolic disease, 43(4), 712-725 (2020-01-14)
Laboratory investigations of cerebrospinal fluid (CSF) are essential when suspecting an inborn error of metabolism (IEM) involving neurological features. Available tests are currently performed on different analytical platforms, requiring a large sample volume and long turnaround time, which often delays
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