SAB5700317

Anti-Phospho-MDM2-S166 antibody produced in rabbit

• Sinónimos: ACTFS, HDMX, MDM2, hdm2
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 11-14; 24-55
• species reactivity: rat, mouse, human
• concentration: 0.63 mg/ml
• technique(s): immunofluorescence: 1:50-1:100; western blot: 1:500-1:1000
• UniProt accession no.: Q00987
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer166)
• Gene Information: human ... MDM2(4193)

Descripción

General description

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Immunogen

A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable