Cluster of differentiation 28 (CD 28) is a lymphocyte surface protein. In human chromosome, the gene CD28 is localized on 2q33.2. The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. HLDA V.; WS Code 5T CD28.05.
Immunogen
DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA
Biochem/physiol Actions
Cluster of differentiation 28 (CD28) acts as a costimulatory molecule for T cell activation and proliferation. CD28 might function as a tumor suppressor gene and the polymorphism is related to increased risk of breast cancer. CD28 plays a key role in allogenic responses. The level of CD28 is upregulated in CD4+ lymphocytes during acute graft rejection. Polymorphism in CD28 owing to higher frequency of CD28 molecule has impact on schizophrenia. Mutations in CD28 is associated with T cell lymphoma′s and neoplasm, leading to accelerated tumour growth. CD28 along with phosphatidylinositol 3 kinase (PI3K) regulates diverse biochemical pathways. CD28 signals to T cells and prevents anergy and apoptosis and promotes T cell proliferation and production of interleukin-2.
Features and Benefits
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Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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CD28 biomarker quantification and expression level profiles in CD4+ T-lymphocytes in solid organ transplantation
Boix F, et al.
Transplant Immunology, 42, 9-17 (2017)
Polymorphisms in immune-inflammatory response genes and the risk of deficit schizophrenia
Mak M, et al.
Schizophrenia Research, 193, 359-363 (2018)
Use of flow-sorted canine chromosomes in the assignment of canine linkage, radiation hybrid, and syntenic groups to chromosomes: refinement and verification of the comparative chromosome map for dog and human
Sargan D, et al.
Genomics, 69(2), 182-195 (2000)
A point mutation in CD28 distinguishes proliferative signals from survival signals
Okkenhaug K, et al.
Nature Immunology, 2(4), 325-332 (2001)
The association between CD28 gene rs3116496 polymorphism and breast cancer risk in Chinese women
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