SAB4504104

Anti-phospho-PKD2 (pSer⁸⁷⁶) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-HSPC187
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 96 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:60000; western blot: 1:500-1:1000
• NCBI accession no.: Q9BZL6
• UniProt accession no.: Q9BZL6
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer876)
• Gene Information: human ... PRKD2(25865)

Descripción

General description

The protein kinase D2 (PRKD2) gene, mapped to human chromosome 4q21-23, codes for integral membrane protein polycystin-2. PRKD2 is a member of the serine/threonine protein kinase D (PRKD) family. It is characterized with two N-terminal cysteine-rich zinc finger domains involved in binding diacylglycerol (DAG) and phorbol esters, a central lipid/protein binding pleckstrin homology (PH) domain, and a C-terminal kinase domain. PRKD2 is mainly expressed in the endoplasmic reticulum (ER).

Immunogen

The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser876.

Immunogen Range: 829-878

Biochem/physiol Actions

Protein kinase D2 (PRKD2) is a novel, essential mediator of tumor cell-endothelial cell communication and a promising therapeutic target to inhibit angiogenesis in gastrointestinal cancers. Mutation in the gene leads to autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 might function as a component of intracellular channel complexes. PRKD2 influences CD8⁺ T cell-dependent immune responses. PKD2 facilitates cell migration and it is associated with the progression and maintenance of various malignancies. Increased expression of PKD2 is observed in various types of cancers including colorectal cancer, glioblastoma multiforme (GBM). CRT0066101 acts as an inhibitor for all the three protein kinase D isoforms. Therefore, it can be used as a therapeutic drug for PRKD2 induced carcinogenesis.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable