SAB4500500

Anti-CSFR antibody produced in rabbit

affinity isolated antibody

• Sinónimos: CD115, CSF-1-R, CSF1R, CSFMR, c-fms
• Número MDL: MFCD00282160
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 107 kDa
• reactividad de especies: human, rat, mouse
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• Nº de acceso NCBI: P07333
• Nº de acceso UniProt: P07333
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CSF1R(1436)

Descripción

Descripción general

Colony stimulating factor 1 receptor (CSF-1R) is encoded by the c-fms proto-oncogene mapped to human chromosome 5q33. The encoded protein acts as a receptor for CSF1 expressed in non-hematopoietic cells, such as macrophages, epithelial and fibroblasts cells and tumor cells.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human CSFR.

Immunogen Range: 531-580

Acciones bioquímicas o fisiológicas

Colony stimulating factor 1 receptor (CSF-1R)/ CSF-1 ligand system plays a vital role in the regulation of macrophage physiology in immune system.The encoded protein functions as a receptor and mediates the function of its ligand, colony stimulating factor 1, a cytokine involved in regulation of production, differentiation, and function of macrophages. Experimental analysis revealed that CSF-1/CSF-1R is overexpressed in patients with nasopharyngeal carcinoma when compared to patients with nasopharyngitis. Activated CSF-1R, is essential for monocyte differentiation to macrophages by oxidized low-density lipoprotein (Ox-LDL), which is a vital step in early atherogenesis. This protein is also associated with regulation of hematopoiesis. Deletion or mutation of this gene might be involved in the pathogenesis of myelodysplastic syndromes or of acute nonlymphocytic leukemia (ANLL).

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable