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SAB4300075

Sigma-Aldrich

Anti-phospho-PRKD1 (pSer910) antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-PKC-MU antibody produced in rabbit, Anti-PKCM antibody produced in rabbit, Anti-PKD antibody produced in rabbit, Anti-PRKCM antibody produced in rabbit, Anti-protein kinase D1 antibody produced in rabbit

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About This Item

MDL number:
MFCD03455823
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~115 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(R-V-SP-I-L)

NCBI accession no.

NP_002733.2

UniProt accession no.

Q15139

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer910)

Gene Information

human ... PRKD1(5587)

Immunogen

Peptide sequence around phosphorylation site of serine 910 (R-V-S(p)-I-L), according to the protein PRKD1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
511711096

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Alexis Bonfim-Melo et al.
Cellular microbiology, 17(12), 1797-1810 (2015-06-23)
Trypanosoma cruzi extracellular amastigotes (EAs) display unique mechanisms for cell invasion that are highly dependent on host actin filaments. Protein kinase D1 (PKD1) phosphorylates and modulates the activity of cortactin, a key regulator of actin dynamics. We evaluated the role
Adrien Pasquier et al.
Nature communications, 10(1), 3312-3312 (2019-07-28)
Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress markedly enhances macroautophagy-independent lysosomal degradation

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