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Key Documents

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S6272

Sigma-Aldrich

Substance P Fragment 1-7

≥97% (HPLC)

Sinónimos:

Arg-Pro-Lys-Pro-Gln-Gln-Phe

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About This Item

Fórmula empírica (notación de Hill):
C41H65N13O10
Número de CAS:
68060-49-1
Peso molecular:
900.04
MDL number:
MFCD00076789
UNSPSC Code:
12352209
PubChem Substance ID:
24899694
NACRES:
NA.26

product name

Substance P Fragment 1-7, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥65%

color

white

UniProt accession no.

P20366

application(s)

cell analysis

storage temp.

−20°C

SMILES string

NCCCCC(NC(=O)C1CCCN1C(=O)C(N)CCCNC(N)=N)C(=O)N2CCCC2C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(Cc3ccccc3)C(O)=O

InChI

1S/C41H65N13O10/c42-19-5-4-12-28(51-37(60)30-13-7-21-53(30)38(61)25(43)11-6-20-48-41(46)47)39(62)54-22-8-14-31(54)36(59)50-27(16-18-33(45)56)34(57)49-26(15-17-32(44)55)35(58)52-29(40(63)64)23-24-9-2-1-3-10-24/h1-3,9-10,25-31H,4-8,11-23,42-43H2,(H2,44,55)(H2,45,56)(H,49,57)(H,50,59)(H,51,60)(H,52,58)(H,63,64)(H4,46,47,48)

InChI key

KPHDBQWTCKBKIL-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe

Biochem/physiol Actions

Fragment that gives depressor and bradycardic effects when applied to the nucleus tractus solitarius

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Qin Zhou et al.
Peptides, 32(8), 1661-1665 (2011-07-19)
The N-terminal substance P fragment SP(1-7) is known to modulate hyperalgesia and opioid withdrawal in animal models. This study examined the effects of intraperitoneal (i.p.) injections of SP(1-7) on chronic morphine tolerance and on the levels of dynorphin B (DYN
Milad Botros et al.
Peptides, 27(4), 753-759 (2005-10-12)
Endomorphin-1 (EM-1) and endomorphin-2 (EM-2) represent two opioid active tetrapeptides with high affinity and selectivity for the mu-opioid (MOP) receptor. Both EM-1 and EM-2 exhibit strong inhibition of pain signals in the central nervous system (CNS). In contrast to these
Qin Zhou et al.
Peptides, 25(11), 1951-1957 (2004-10-27)
The aminoterminal fragment of substance P (SP), SP(1-7), has been suggested to modulate the expression of opiate tolerance and withdrawal behaviors in rodents. However, the mechanism of this effect is not yet clarified. Using a rat model we have previously
Anna Carlsson et al.
European journal of pharmacology, 626(2-3), 250-255 (2009-10-20)
We have recently explored the role of the tachykinin substance P neuroactive fragment substance P(1-7) in the mediation of anti-inflammatory effects using a blister model in the rat paw (Wiktelius et al., 2006). We observed that this heptapeptide induced a
Takaaki Komatsu et al.
Neuropharmacology, 61(4), 608-613 (2011-05-24)
Previous research has demonstrated that substance P N-terminal fragments produced by the action of several different enzymes in the spinal cord could reduce nociception when injected intrathecally (i.t.) into mice. The present study examined the possible involvement of spinal extracellular
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