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RAB0543

Sigma-Aldrich

Human IL18 / Interleukin-18 ELISA Kit

for serum, plasma, cell culture supernatants and urine

Sinónimos:

IFN-gamma-inducing factor, IL-18, Interleukin-18 

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type urine
sample type plasma
sample type serum

assay range

inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 0.5 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL18(3606)

Categorías relacionadas

General description

The antibody pair provided in this kit detects Human IL-18 in serum, plasma, cell culture supernatants, and urine. Interleukin-18 (IL-18) is a proinflammatory cytokine, expressed in most of the mammalian tissues including adipose, liver and skeletal muscle. It is generated as pro-IL-18 which undergoes cleavage to form a mature IL-18 possessing the signal peptide. IL-18 induces Th1 (T helper cell 1) lymphocyte action mediated by interferon-γ. It controls the metabolism of lipids and glucose. Inflammasome activation is responsible for IL-18 release, which is a significant event in response to viral infection. Increased level of IL-18 is observed in kidney and liver disease, diabetes, atherosclerosis, autoimmune disease such as rheumatoid arthritis and asthma. It is also associated with the development of renal dysfunction.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human IL18 / Interleukin-18 ELISA Kit has been used to evaluate the macrophage cytokines production in response to trans-stilbene and terphenyl compounds. It has also been used to analyze and measure IL-18 levels in the urine of chronic kidney disease patients.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Effects of trans-stilbene and terphenyl compounds on different strains of Leishmania and on cytokines production from infected macrophages
Bruno F, et al.
Experimental Parasitology, 184(1), 31-38 (2018)
Victor Edgar Fiestas Solórzano et al.
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The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines
Vaios Vasileios Kaminiotis et al.
Lipids in health and disease, 16(1), 184-184 (2017-09-28)
Atherosclerosis is a chronic inflammatory disease that is promoted, among others, by pro-inflammatory cytokines such as IL-1β and IL-18 produced by NLRP 3 inflammasome. Development of atherosclerotic lesions is also affected by leptin. Furthermore, inflammasome's action is interfered with other
Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry
Ulke-Lemee A, et al.
Inflammation, 41(4), 1396-1408 (2018)
Anna Permyakova et al.
Frontiers in endocrinology, 11, 91-91 (2020-03-29)
Both diabetes and obesity (diabesity) contribute significantly to the development of chronic kidney disease (CKD). In search of new remedies to reverse or arrest the progression of CKD, we examined the therapeutic potential of a novel compound, AN1284, in a
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