P3134
Phosphodiesterase I from Crotalus adamanteus venom
Type VI, crude dried venom
Sinónimos:
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
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About This Item
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General description
Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.
Application
Phosphodiesterase I from Crotalus adamanteus venom has been used:
- for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
- as a model for the hydrolysis of prodrugs in phosphodiesterase assay
- as a component in the nucleotide cleavage buffer
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca2+/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.
inhibitor
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Descripción
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substrate
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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