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N9412

Sigma-Aldrich

6β-Naltrexol hydrate

≥96% (HPLC), powder

Sinónimos:

(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol hydrate

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About This Item

Fórmula empírica (notación de Hill):
C20H25NO4 · xH2O
Número de CAS:
1034528-53-4
Peso molecular:
343.42 (anhydrous basis)
MDL number:
MFCD08277038
UNSPSC Code:
12352200
PubChem Substance ID:
24724560
NACRES:
NA.77

Quality Level

100

assay

≥96% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

DMSO: ~12 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

[H]O[H].O[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CC6)c45

InChI

1S/C20H25NO4.H2O/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,14-15,18,22-24H,1-2,5-10H2;1H2/t14-,15-,18+,19+,20-;/m1./s1

InChI key

VHGGWFVHXKTOPK-CDHBEYIESA-N

Biochem/physiol Actions

Neutral antagonist of the μ-opioid receptor. A reduction of withdrawal effects associated with neutral μ-opioid receptor antagonists may offer advantages in treating opioid overdose and addiction.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

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Visite la Librería de documentos

Kirsten M Raehal et al.
The Journal of pharmacology and experimental therapeutics, 313(3), 1150-1162 (2005-02-18)
The mu-opioid receptor displays basal signaling activity, which seems to be enhanced by exposure to opioid agonists. This study assesses the in vivo pharmacology of the putative "neutral" antagonist 6beta-naltrexol in comparison to other ligands with varying efficacy, such as
Robyn St Laurent et al.
Neuron, 106(4), 624-636 (2020-03-20)
The ventral tegmental area (VTA) is a major target of addictive drugs and receives multiple GABAergic projections originating outside the VTA. We describe differences in synaptic plasticity and behavior when optogenetically driving two opiate-sensitive GABAergic inputs to the VTA, the rostromedial

Artículos

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

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