M3262

N-Methyl-D-aspartic acid

≥98% (TLC), suitable for cell culture

• Sinónimos: (R)-2-(Methylamino)succinic acid, NMDA
• Fórmula empírica (notación de Hill): C₅H₉NO₄
• Número de CAS: 6384-92-5
• Peso molecular: 147.13
• Beilstein: 1724431
• Número MDL: MFCD00004226
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24277987
• NACRES: NA.32

Propiedades

• Nombre del producto: N-Methyl-D-aspartic acid, ≥98% (TLC), solid
• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: solid
• técnicas: cell culture | mammalian: suitable
• color: white
• mp: 189-190 °C
• aplicaciones: cell analysis
• cadena SMILES: CN[C@H](CC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
• Clave InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-N
• Información sobre el gen: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907) ; rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)

Descripción

Descripción general

N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.[1]

Aplicación

N-Methyl-D-aspartic acid has been used to induce N-methyl-d-aspartic acid (NMDA) toxicity, cultures of retinal cells were supplemented with NMDA.[2][3]

Acciones bioquímicas o fisiológicas

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.

N-Methyl-D-aspartic acid (NMDA) plays a crucial role in release of luteinizing hormone and PRL (prolactin) in the pituitary gland and GnRH (gonadotropin releasing hormone) in the hypothalamus.[1][4] It acts as a specific agonist for NMDA type glutamate receptors.[4]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)