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Merck

M1946

Sigma-Aldrich

Anti-monoaminooxidasa B (C-terminal) antibody produced in rabbit

enhanced validation

affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution

Sinónimos:

Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~58 kDa

species reactivity

rat, mouse, human

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Categorías relacionadas

General description

Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.

Specificity

Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.

Application

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

Physical form

Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia
Sun J, et al.
Psychiatry Research, 198(2), 202-206 (2012)
MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology
Mallajosyula JK, et al.
PLoS ONE, 3(2), e1616-e1616 (2008)
PET imaging for addiction medicine: From neural mechanisms to clinical considerations
Wiers CE, et al.
Progress in Brain Research, 224, 175-201 (2016)
Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases
Edmondson DE, et al.
Biochemistry, 48(20), 4220-4220 (2009)
A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
Dann J, et al.
Psychiatry Research, 70(3), 131-143 (1997)

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