I8904

Insulin-like Growth Factor-II from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• Sinónimos: IGF-II
• Número MDL: MFCD00241895
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Insulin-like Growth Factor-II from mouse, IGF-II, recombinant, expressed in E. coli, lyophilized powder
• origen biológico: mouse
• Nivel de calidad: 100
• recombinante: expressed in E. coli
• Ensayo: >97% (SDS-PAGE)
• Formulario: lyophilized powder
• calidad: endotoxin tested
• mol peso: ~7.4 kDa
• envase: pkg of 5X50 μg; pkg of 50 μg
• impurezas: <1.0EUper1mg (LAL test)
• Nº de acceso UniProt: P09535
• temp. de almacenamiento: −20°C
• Información sobre el gen: mouse ... IGF2(16002) , Igf2(16002)

Descripción

Descripción general

Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.

Acciones bioquímicas o fisiológicas

Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.

Forma física

Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.

Nota de análisis

The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)