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HPA031131

Sigma-Aldrich

Anti-KCNV2 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinónimos:

Anti-Kv8.2, Anti-potassium channel, subfamily V, member 2

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About This Item

Código UNSPSC:
12352203
Atlas de proteínas humanas número:
NACRES:
NA.43

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Línea del producto

Prestige Antibodies® Powered by Atlas Antibodies

Formulario

buffered aqueous glycerol solution

reactividad de especies

human

técnicas

immunohistochemistry: 1:500-1:1000

secuencia del inmunógeno

WNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELA

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KCNV2(169522)

Descripción general

The KCNV2 (potassium channel, subfamily V, member 2) gene is mapped to human chromosome 9p24.2. KCNV2 is highly expressed in retinal photoreceptors. It encodes a modulatory subunit of the Kv8.2, voltage-gated potassium channel.

Inmunógeno

potassium channel, subfamily V, member 2 recombinant protein epitope signature tag (PrEST)

Aplicación

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Acciones bioquímicas o fisiológicas

KCNV2 (potassium channel, subfamily V, member 2) significantly influences the initiation and shaping of action potentials. KCNV2 mutations might lead to febrile, afebrile partial seizures, and epileptic encephalopathy. Alterations in KCVN2 gene might cause an abnormality in photoreceptor membrane potentials by inhibiting proper assembly of heteromeric voltage-gated potassium channels following a pathologically sustained outward potassium current in the dark. Mutation in the gene causes cone dystrophy with supernormal rod responses.

Características y beneficios

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST73048

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
Debette S
Circulation Research, 109(5), 554-563 (2011)
Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants.
Fujinami K
Molecular Vision, 19, 1580-1590 (2013)
Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
Qu J
Medicine, 96(26) (2017)
Novel compound heterozygous mutations resulting in cone dystrophy with supernormal rod response.
Lenis TL
JAMA Ophthalmology, 131(11), 1482-1485 (2013)
Jacqueline Gayet-Primo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(14), 3414-3427 (2018-02-28)
Silent voltage-gated potassium channel subunits (KVS) interact selectively with members of the KV2 channel family to modify their functional properties. The localization and functional roles of these silent subunits remain poorly understood. Mutations in the KVS subunit, KV8.2 (KCNV2), lead

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