H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• Sinónimos: 2-(4-Imidazolyl)ethylamine
• Fórmula empírica (notación de Hill): C₅H₉N₃
• Número de CAS: 51-45-6
• Peso molecular: 111.15
• Beilstein: 2012
• Número CE: 200-100-6
• Número MDL: MFCD00005210
• Código UNSPSC: 12352116
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24895783
• NACRES: NA.77

Propiedades

• Nombre del producto: Histamine, ≥97.0%
• Ensayo: ≥97.0%
• bp: 167 °C/0.8 mmHg (lit.)
• mp: 83-84 °C (lit.)
• temp. de almacenamiento: −20°C
• cadena SMILES: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• Clave InChI: NTYJJOPFIAHURM-UHFFFAOYSA-N
• Información sobre el gen: human ... CA1(759) , CA2(760) , HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340) ; rat ... Hrh1(24448) , Hrh3(85268)

Descripción

Descripción general

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Aplicación

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Acciones bioquímicas o fisiológicas

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H315,H317,H319,H334,H335
• Consejos de prudencia: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves