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G4923

Sigma-Aldrich

(E)-Guggulsterone

≥95% (HPLC), powder

Sinónimos:

(17E)-Pregna-4,17(20)-diene-3,16-dione

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About This Item

Fórmula empírica (notación de Hill):
C21H28O2
Número de CAS:
39025-24-6
Peso molecular:
312.45
MDL number:
MFCD01310758
UNSPSC Code:
12352205
PubChem Substance ID:
329799934
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: soluble 5 mg/mL

functional group

ketone

shipped in

ambient

storage temp.

2-8°C

SMILES string

C\C=C1\C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1

InChI key

WDXRGPWQVHZTQJ-AUKWTSKRSA-N

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Categorías relacionadas

Biochem/physiol Actions

Naturally occuring bioactive plant sterol isolated from the gum resin of guggul (Commiphora wightii). Antihyperlipidemic. Induces the expression of human CYP3A.. Guggulsterone potently reverses multi-drug resistance in a number of human cancer cell lines, extending the efficacy of chemotherapy.

related product

Referencia del producto
Descripción
Precios

G5168

(Z)-Guggulsterone, ≥89% (HPLC), powder

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H335,H412

Hazard Classifications

Aquatic Chronic 3 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hyukjae Choi et al.
Journal of natural products, 74(1), 90-94 (2010-12-15)
One isoprenoid, tuberatolide A (1), meroterpenoids tuberatolide B (2) and 2'-epi-tuberatolide B (3), and the known meroterpenoids yezoquinolide (4), (R)-sargachromenol (5), and (S)-sargachromenol (6) were isolated from the Korean marine tunicate Botryllus tuberatus. The structures of these compounds were elucidated
Sang-Jip Nam et al.
Journal of natural products, 70(11), 1691-1695 (2007-11-09)
Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the
Inas Almazari et al.
Topics in current chemistry, 329, 35-60 (2012-08-02)
Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms.
Chunhua Zhu et al.
Lipids in health and disease, 10, 199-199 (2011-11-08)
Apolipoprotein M (apoM) may have potential antiatherosclerotic properties. It has been reported that apoM expression could be regulated by many intracellar and extracellar factors. In the present study we further investigated regulation of apoM expression in Caco-2 cells stimulated by
Jae-Jun Song et al.
International journal of pediatric otorhinolaryngology, 74(12), 1384-1387 (2010-10-26)
Guggulsterone is a bioactive constituent of resinous sap originating from the guggul tree, Commiphora mukul, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. However, the effect of guggulsterone inflammatory reactions
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