F0756

Fusidic acid

Antibiotic

• Sinónimos: Ramycin
• Fórmula empírica (notación de Hill): C₃₁H₄₈O₆
• Número CAS: 6990-06-3
• Peso molecular: 516.71
• NACRES: NA.77
• PubChem Substance ID: 57654174
• UNSPSC Code: 12352106
• EC Number: 230-256-0
• MDL number: MFCD00865135

Propiedades

• Nombre del producto: Fusidic acid,
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C
• InChI: 1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
• InChI key: IECPWNUMDGFDKC-MZJAQBGESA-N

Descripción

Application

Fusidic acid has been used:

• as a standard in thin-layer chromatography (TLC)-densitometric method
• to study its ability to bind to human serum albumin
• as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves