E4630
Ethambutol dihydrochloride
antimycobacterial
Sinónimos:
Ethambutol, Ethambutol HCL, 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb
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Fórmula empírica (notación de Hill):
C10H24N2O2 · 2HCl
Número CAS:
Peso molecular:
277.23
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51281511
EC Number:
213-970-7
MDL number:
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Servicio técnico
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Permítanos ayudarleQuality Level
form
powder
optical activity
[α]25/D 6.0 to 6.7°, c = 10 in water
color
white
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
mycobacteria
mode of action
cell wall synthesis | interferes
SMILES string
CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
InChI
1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key
AUAHHJJRFHRVPV-BZDVOYDHSA-N
Application
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance.
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.
Biochem/physiol Actions
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.
Ethambutol specifically inhibits arabinosyltransferases in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria.
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| mode of action cell wall synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| form powder | form powder | form - | form - |
| solubility H2O: 50 mg/mL | solubility - | solubility - | solubility - |
| color white | color - | color - | color - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Hassan Safi et al.
Nature genetics, 45(10), 1190-1197 (2013-09-03)
To study the evolution of drug resistance, we genetically and biochemically characterized Mycobacterium tuberculosis strains selected in vitro for ethambutol resistance. Mutations in decaprenylphosphoryl-β-D-arabinose (DPA) biosynthetic and utilization pathway genes Rv3806c, Rv3792, embB and embC accumulated to produce a wide
Hao Zeng et al.
International journal of clinical and experimental medicine, 8(6), 8398-8414 (2015-08-27)
To introduce a modified method, namely coaxial electrohydrodynamic atomization for the fabrication of distinct core/shell structured microspheres of four first-line ant-tuberculosis drugs with different characteristics in hydrophilic properties in one single step. In group B, we prepared microspheres in which
Mohammed Shafik El-Ridy et al.
Drug delivery, 22(1), 21-36 (2013-12-24)
Tuberculosis (TB) is a worldwide health concern. In 2011, about 8.7 million new cases developed TB and 1.4 million people died from it. Enhancement of ethambutol hydrochloride activity and safety in treatment of TB through niosomal encapsulation. Niosomes were prepared
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| E4630-25G | 04061833603864 |
| E4630-100G | 04061833603857 |