This product is tested for solubility at 10mg/mL in 0.2M Tris, pH 8.8, resulting in a turbid solution. A clear solution has not been obtained. A further purified, salt-free version of this material, product E6527, produces a clear to hazy solution in water at 10mg/mL. Please see the link below to review a sample or lot-specific Certificate of Analysis for this item:
https://www.sigmaaldrich.com/product/sigma/e6527#product-documentation
E1625
Elastin from bovine neck ligament
powder
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About This Item
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Productos recomendados
origen biológico
bovine neck ligament
Nivel de calidad
Formulario
powder
Nº de acceso UniProt
temp. de almacenamiento
2-8°C
cadena SMILES
N1([C@@H](CCC1)C(=O)NC)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)[C@H](CC)C)C(C)C
InChI
1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
Clave InChI
DPUYCSDGMSDKKV-MKBYFEBXSA-N
Información sobre el gen
cow ... ELN(280781)
Aplicación
Elastin is a structural protein which has been used in studies of Chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.
Acciones bioquímicas o fisiológicas
Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
H M Morrison et al.
Biochimica et biophysica acta, 1430(2), 179-190 (1999-03-20)
Solubilization of elastin by human leukocyte elastase (HLE) cannot be analyzed by conventional kinetic methods because the biologically relevant substrate is insoluble and the concentration of enzyme-substrate complex has no physical meaning. We now report quantitative measurements of the binding
Katsuhiko Tsuchida et al.
Scientific reports, 10(1), 21667-21667 (2020-12-12)
Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has
N Vyavahare et al.
The American journal of pathology, 155(3), 973-982 (1999-09-17)
Elastin, an abundant structural protein present in the arterial wall, is prone to calcification in a number of disease processes including porcine bioprosthetic heart valve calcification and atherosclerosis. The mechanisms of elastin calcification are not completely elucidated. In the present
Isabella C P Rodrigues et al.
Artificial organs, 45(5), E113-E122 (2020-11-11)
Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists
Xiaozhuo Shao et al.
Journal of biomedical optics, 16(6), 067005-067005 (2011-07-05)
The aim of this study is to evaluate the biochemical foundation and clinical capability of an image-guided near-infrared (NIR) autofluorescence (AF) spectroscopy technique for in vivo diagnosis of colonic malignancies during clinical colonoscopy. A novel endoscopic fiber-optic AF system was
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Hello, I was wondering if you can recommend any procedures for dissolving the powder? I have tried in 0.2M Tris pH8.8 at 10mg/mL, as recommend in literature without success.
1 answer-
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