E0287
Carboxylesterase 1 isoform b human
recombinant, expressed in baculovirus infected BTI insect cells
Sinónimos:
Carboxylesterase 1 human, carboxylesterase, esterase
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About This Item
Productos recomendados
recombinante
expressed in baculovirus infected BTI insect cells
Nivel de calidad
Formulario
liquid
actividad específica
≥500 units/mg protein
concentración
5 mg/mL
peso
(0.5 ml)
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
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Descripción general
Carboxylesterase (CE) belongs to serine hydrolase family. It is widely present in the human body. Five isoforms of carboxylesterase is present in humans. It is encoded by CES1 gene mapped to 16q22.2 in human chromosome.
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Aplicación
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner. It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ.
Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Acciones bioquímicas o fisiológicas
Carboxylesterase (CE) is implicated in drug metabolism in liver and hepatic steatosis. Deficiency of CE in humans causes obesity, hyperlipidemia, insulin insensitivity, and cancer.
Definición de unidad
One unti will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37°C
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Resp. Sens. 1
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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