D7321

Diosmetin

• Sinónimos: 3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether
• Fórmula empírica (notación de Hill): C₁₆H₁₂O₆
• Número de CAS: 520-34-3
• Peso molecular: 300.26
• Beilstein: 294492
• Número CE: 208-291-8
• Número MDL: MFCD00017425
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 329798848
• NACRES: NA.25

Propiedades

• Ensayo: ≥98% (HPLC)
• Nivel de calidad: 200
• Formulario: powder
• color: light yellow to yellow
• solubilidad: DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
• Clave InChI: MBNGWHIJMBWFHU-UHFFFAOYSA-N

Descripción

Descripción general

Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.

Aplicación

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.

Acciones bioquímicas o fisiológicas

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).

Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable