D5446
7,8-Dihydroxyflavone hydrate
≥98% (HPLC)
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About This Item
Fórmula empírica (notación de Hill):
C15H10O4 · xH2O
Número de CAS:
Peso molecular:
254.24 (anhydrous basis)
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
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Ensayo
≥98% (HPLC)
Formulario
solid
condiciones de almacenamiento
desiccated
solubilidad
DMSO: 24 mg/mL
temp. de almacenamiento
room temp
cadena SMILES
Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
InChI
1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
Clave InChI
COCYGNDCWFKTMF-UHFFFAOYSA-N
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Aplicación
7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).
Acciones bioquímicas o fisiológicas
7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.
7,8-Dihydroxyflavone is a selective TrkB receptor agonist
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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