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D1507

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

Name: <SC>L</SC>-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, L-DOPA precursor

Sinónimos:

Methyl L-DOPA hydrochloride

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About This Item

Fórmula empírica (notación de Hill):

C₁₀H₁₃NO₄ · HCl

Número de CAS:

1421-65-4

Peso molecular:

247.68

MDL number:

MFCD00038958

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24278358

NACRES:

NA.77

En este momento no podemos mostrarle ni los precios ni la disponibilidad

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Sigma-Aldrich

D9628

3,4-Dihidroxi-L-fenilalanina

Supelco

PHR1271

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Benserazide hydrochloride

Sigma-Aldrich

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6-Hydroxydopamine hydrochloride

Sigma-Aldrich

SML0091

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D3900

Desipramine hydrochloride

Sigma-Aldrich

H8502

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M0896

1-Metil-4-fenil-1,2,3,6-tetrahidropiridina hydrochloride

Sigma-Aldrich

R8875

Rotenone

Nombre del producto

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride, solid

form

solid

Quality Level

200

color

white to off-white

storage temp.

−20°C

SMILES string

Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1

InChI

1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1

InChI key

WFGNJLMSYIJWII-FJXQXJEOSA-N

Application

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:

in treating 6-hydroxydopamine induced lesions mice serotonin neurons[1]
in tyrosinase activity in B16F10 skin melanoma cells[2]
to test its neuroprotective effect in mesencephalic neurons[3]

Biochem/physiol Actions

L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to L-DOPA[4] that crosses the blood-brain barrier.[5] Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.[6]

Caution

Light sensitive

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Supelco

PHR1271

3,4-Dihidroxi-L-fenilalanina

USP

1361009

3,4-Dihidroxi-L-fenilalanina

Sigma-Aldrich

857416

(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate

Sigma-Aldrich

8.52093

Fmoc-DOPA(acetonide)-OH

BP685

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Sigma-Aldrich

M4255

3-Methoxy-L-tyrosine monohydrate

Sigma-Aldrich

T3824

Tirosinasa from mushroom

Sigma-Aldrich

K3125

Kojic acid

M1500000

Methyldopa

L-Dopa methyl ester as a new antitumour agent

Wick MM

Nature, 269(5628), 512-513 (1977)

Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillations.

Kevin W McCairn et al.

Journal of neurophysiology, 101(4), 1941-1960 (2009-01-24)

Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease. To investigate this question, we studied the spontaneous activity of 102 pallidal neurons during

Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum.

Muriel Geurts et al.

Neuroscience letters, 333(2), 146-150 (2002-11-07)

The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by

Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats.

Xinxin Yang et al.

International journal of nanomedicine, 7, 2077-2086 (2012-05-24)

Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. In this study, we prepared levodopa methyl

3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA

Asanuma M and Miyazaki I

BMC Neuroscience, 17(1), 52-52 (2016)

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Documentos clave

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride

≥98% (HPLC), solid, L-DOPA precursor

About This Item

Productos recomendados

Propiedades

Nombre del producto

form

Quality Level

color

storage temp.

SMILES string

InChI

InChI key

Descripción

Application

Biochem/physiol Actions

Caution

Other Notes

Información de seguridad

Storage Class

wgk_germany

flash_point_f

flash_point_c

Documentación

Certificados de análisis (COA)

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