B5936

Brefeldin A

Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

• Sinónimos: Synergisidin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
• Fórmula empírica (notación de Hill): C₁₆H₂₄O₄
• Número CAS: 20350-15-6
• Peso molecular: 280.36
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 329773270
• MDL number: MFCD12913297
• Beilstein/REAXYS Number: 25191

Propiedades

• biological source: Penicillium brefeldianum
• Quality Level: 200
• vapor pressure: 0.56 hPa ( 20 °C)
• form: ready-to-use solution
• autoignition temp.: 301 °C
• concentration: 10 mg/mL in DMSO
• solubility: DMSO: 10 mg/mL
• antibiotic activity spectrum: neoplastics
• application(s): advanced drug delivery
• mode of action: cell membrane | interferes
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
• InChI: 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
• InChI key: KQNZDYYTLMIZCT-KQPMLPITSA-N

Descripción

Application

Brefeldin A produced from Penicillium brefeldianum may be used to study protein and lipid transport between Golgi complex and the cell surface.

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties.

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Hygroscopic.Storage class (TRGS 510): Combustible liquids

Información de seguridad

• Clase de almacenamiento: 10 - Combustible liquids
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)