B4563

Bisantrene dihydrochloride

≥98% (HPLC)

• Sinónimos: Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride, NSC 337766
• Fórmula empírica (notación de Hill): C₂₂H₂₂N₈ ·2HCl
• Número de CAS: 78186-34-2
• Peso molecular: 471.39
• Número MDL: MFCD01743164
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329773240
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: solid
• condiciones de almacenamiento: desiccated
• solubilidad: deionized water: 8 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.Cl.C1CN=C(N1)N\N=C\c2c3ccccc3c(\C=N\NC4=NCCN4)c5ccccc25
• InChI: 1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
• Clave InChI: KINULKKPVJYRON-PVNXHVEDSA-N

Descripción

Aplicación

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

Acciones bioquímicas o fisiológicas

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator and topoisomerase II poison

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.

Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H302,H400
• Consejos de prudencia: P273 - P301 + P312 + P330
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Acute 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable