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Key Documents

A9847

Sigma-Aldrich

Angiopoietin-2 human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sinónimos:

Ang-2

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About This Item

MDL number:
MFCD01867019
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

66 kDa by SDS-PAGE (reducing and non-reducing conditions)
 66 kDa by SDS-PAGE

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

O15123

storage temp.

−20°C

Gene Information

human ... ANGPT2(285)

Biochem/physiol Actions

This ligand is a naturally occurring inhibitor of angiopoietin-1 and Tie-2 both in vivo and in vitro, and has important roles in embryogenic angiogenesis and maintaining the integrity of adult vasculature.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 500 mM NaCl, 0.1% PEG-8000, 0.2% CHAPS, pH 7.0 containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured a competitive binding assay.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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B Witzenbichler et al.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1.
Yang, et al.
Cell Death & Disease, 14, 344-344 (2023)
Hsiu-Mei Chen et al.
Oncotarget, 6(17), 14940-14952 (2015-04-25)
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However

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