A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

• Sinónimos: ATP, 5′-ATP-K₂
• Fórmula empírica (notación de Hill): C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O
• Número de CAS: 42373-41-1
• Peso molecular: 583.36 (anhydrous basis)
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891383
• NACRES: NA.51

Propiedades

• biological source: microbial
• assay: ≥92% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

Descripción

General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

• in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
• as a component of energy solution for calibrating crude cell extract
• to test its dependency with PK11195 in mediating autophagy

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Caution

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves