424M-1

CITED1 (5H6) Mouse Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: ascites fluid
• tipo de anticuerpo: primary antibodies
• clon: 5H6, monoclonal
• descripción: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (424M-14); vial of 0.5 mL concentrate (424M-15); bottle of 1.0 mL predilute (424M-17); vial of 1.0 mL concentrate (424M-16); bottle of 7.0 mL predilute (424M-18)
• fabricante / nombre comercial: Cell Marque^®
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• isotipo: IgG2aκ
• control: Wilms’ tumor
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: nuclear
• Información sobre el gen: human ... CITED1(4435)

Descripción

Descripción general

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.^1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.³ Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.¹ CITED1 expression has been shown to persist in blastemal cell populations of human WT.^1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.^1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.¹ CITED1 has been detected in 86.8% of WT Cases.²

Calidad

IVD

IVD

IVD

RUO

Ligadura / enlace

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

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Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany