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424M-1

Sigma-Aldrich

CITED1 (5H6) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

5H6, monoclonal

descripción

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (424M-14)
vial of 0.5 mL concentrate (424M-15)
bottle of 1.0 mL predilute (424M-17)
vial of 1.0 mL concentrate (424M-16)
bottle of 7.0 mL predilute (424M-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotipo

IgG2aκ

control

Wilms’ tumor

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

nuclear

Información sobre el gen

human ... CITED1(4435)

Descripción general

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.3 Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.1 CITED1 expression has been shown to persist in blastemal cell populations of human WT.1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.1 CITED1 has been detected in 86.8% of WT Cases.2

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Harold N Lovvorn et al.
Neoplasia (New York, N.Y.), 9(7), 589-600 (2007-08-22)
Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators
Andrew J Murphy et al.
Journal of pediatric surgery, 47(6), 1239-1249 (2012-06-19)
SIX2 and CITED1 are transcriptional regulators that specify self-renewing nephronic progenitor cells of the embryonic kidney. We hypothesized that SIX2, which promotes and maintains this stem cell population, and CITED1 remain active in Wilms' tumor (WT). To evaluate expression domains
Scott Boyle et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 236(8), 2321-2330 (2007-07-07)
Early kidney development in mammals is characterized by reciprocal tissue interaction between the ureteric bud and the metanephric mesenchyme. The coordinated response to this interaction is regulated largely at the transcriptional level. Here, we investigate the expression and function of

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