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16758

Poli(etilenglicol)-bloque-poli(propilenglicol)-bloque-poli(etilenglicol))

purified, non-ionic

Sinónimos:

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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A ustedes/SKUDisponibilidadPrecio
250 g

Envío estimado HOYdesdeSAINT LOUIS

USD 230.74

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Número CAS:
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:

USD 230.74


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Quality Segment

form

powder

quality

purified

impurities

≤1.0% water

pH

5.0-7.5

solubility

soluble, clear, colorless

cation traces

Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

UV absorption

λ: 260 nm Amax: ≤0.3, λ: 280 nm Amax: ≤0..2

suitability

no residue for filter test

storage temp.

2-8°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:
  • as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
  • for VLDL secretion assay in mice
  • to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Biochem/physiol Actions

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

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Este artículo
620351.37112K4894
suitability

no residue for filter test

suitability

-

suitability

-

suitability

-

form

powder

form

powder

form

solid

form

solid

storage temp.

2-8°C

storage temp.

-

storage temp.

2-25°C

storage temp.

-

impurities

≤1.0% water

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤0.75% water, ≤1 ppm ethylene oxide, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-125 ppm butylhydroxytoluene

impurities

-

impurities

-

solubility

soluble, clear, colorless

solubility

10%, clear, colorless

solubility

-

solubility

-

Quality Level

100

Quality Level

100

Quality Level

500

Quality Level

300


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What does the number in poloxamer-407, 105, 108, etc. stand for?

    1 answer
    1. The numeric suffix in various forms of Poloxamers refers to the mass per mole of polyoxypropylene and the percentage of polyoxyethylene present in that specific compound.

      Helpful?

  4. In poloxamer-407,105, 108 etc. This number stands for?

    1 answer
    1. Poloxamers are block co-polymers that have a basic structure of one central polyoxypropylene core adjoined to two polyoxyethylene side blocks or chains. The numeric suffix designated in various forms of Poloxamers is in reference to the mass per mole of polyoxypropylene and the percentage of polyoxyethylene present within that specific compound.
      See the link below for additional information. Examples can be found in Table 1 on page 2.

      https://nmr.oxinst.com/assets/uploads/MagRes/App%20Notes/X-Pulse/App_Note_3_Poloxamer_Oct_2019.pdf

      Helpful?

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