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Key Documents

MABN53

Sigma-Aldrich

Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9

clone 3D9, from mouse

Sinónimos:

Dopamine D2 receptor

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

3D9, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

human (immunogen homology)

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DRD2(1813)
rat ... Drd2(24318)

General description

Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics.

Immunogen

Linear peptide corresponding to human Dopamine D2 receptor.

Application

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.
This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).

Quality

Evaluated by Western Blot in rat spinal cord tissue lysate.

Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.

Target description

~50 kDa observed

Physical form

Format: Purified

Analysis Note

Control
Rat spinal cord tissue lysate

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Dasiel O Borroto-Escuela et al.
Frontiers in molecular neuroscience, 16, 1106765-1106765 (2023-06-09)
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration. Ex vivo studies using
Dasiel O Borroto-Escuela et al.
Molecular neurobiology, 56(10), 7045-7055 (2019-04-12)
The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (D2R)-sigma 1 receptor (δ1R) heteroreceptor complexes and the D2R protomer recognition, signaling and internalization in cellular models.
Dasiel O Borroto-Escuela et al.
Frontiers in pharmacology, 9, 829-829 (2018-09-15)
The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allosteric interactions across the A2AR-D2R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinants
Dasiel O Borroto-Escuela et al.
Neurotoxicity research, 37(2), 433-444 (2019-11-30)
Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely
Wilber Romero-Fernandez et al.
Molecular neurobiology, 59(10), 5955-5969 (2022-07-14)
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that

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