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Documentos clave

MABD123

Sigma-Aldrich

Anti-Osteocalcin Antibody, Clone 7D1.13

clone 7D1.13, from mouse

Sinónimos:

Bone Gla protein, BGP, BGLAP, Gamma-carboxyglutamic acid-containing protein

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

7D1.13, monoclonal

reactividad de especies

human

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable

isotipo

IgG1κ

Nº de acceso NCBI

NP_954642

Nº de acceso UniProt

P02818

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... BGLAP(632)

Descripción general

Osteocalcin is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Osteocalcin is often studied in the osteogenesis of embryonic and mesenchymal stem cells.

Inmunógeno

KLH-conjugated linear peptide corresponding to Human Osteocalcin.

Aplicación

Detect Osteocalcin using this mouse monoclonal antibody, Anti-Osteocalcin Antibody, Clone 7D1.13 validated for use in IHC (Paraffin) & IHC (tissue).
Research Sub Category
Mesenchymal Stem Cells

Osteobiology

Calidad

Evaluated by Immunohistochemistry on human trabecular bone in a human bone biopsy.
Immunohistochemical Analysis: A 1:50 Dilution of this antibody detected osteocalcin on human trabecular bone in a human bone biopsy.

Descripción de destino

~6 kDa calculated

Ligadura / enlace

Replaces: MABD182

Forma física

Format: Purified

Nota de análisis

Control
Human trabecular bone in a human bone biopsy.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hao Cheng et al.
Acta biomaterialia, 69, 342-351 (2018-01-26)
The inorganic part of human bone is mainly composed of hydroxyapatite (HAP: Ca10(PO4)6(OH)2) and whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) minerals, where the WH phase occupies up to 20-35% of total weight. These two bone minerals have different crystal structures and physicochemical properties
Zhe Shi et al.
International journal of nanomedicine, 15, 9337-9353 (2020-12-03)
Autologous bone grafts are the gold standard for treating bone defects. However, limited bone supply and morbidity at the donor site restrict its extensive use. Therefore, developing bone graft materials as an alternative to autologous grafts has gained considerable attention.
Zhe Shi et al.
International journal of nanomedicine, 16, 5603-5619 (2021-08-26)
Given that autologous bone graft for bone defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic graft materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic materials that could integrate the
Stylianos Kosmidis et al.
Cell reports, 25(4), 959-973 (2018-10-26)
Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the

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