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Key Documents

MAB3414

Sigma-Aldrich

Anti-Cytokeratin 8 Antibody, clone 4.1.18

clone 4.1.18, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.1.18, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KRT8(3856)

Specificity

The antibody reacts with human cytokeratin 8. There is no cross reactivity with human cytokeratin No. 7, 17, 18, or 19. Anti-cytokeratin No. 8 decorates single epithelia in stomach, colon, and small intestine, gall bladder, liver (bile ducts and hepatocytes) as well as pancreatic ducts and mammary gland ducts.

Immunogen

Cytoskeletal preparation of MCF-7 cells.

Application

This Anti-Cytokeratin 8 Antibody, clone 4.1.18 is validated for use in WB, IC, IH, IH(P) for the detection of Cytokeratin 8.
Western blot Immunocytochemistry Immunohistochemistry: Frozen sections, acetone fixed (5-10 μg/mL)

Paraffin sections, after trypsin treatment (5-20 μg/mL)

Optimal-working dilutions must be determined by end user.

Linkage

Replaces: 04-588

Physical form

Format: Purified
Lyophilized from 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Optional

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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While remaining extracellular, enteropathogenic Escherichia coli (EPEC) establish direct links with the cytoskeleton of the target epithelial cell leading to the formation of actin-rich pedestals underneath attached bacteria. The translocated adaptor protein Tir forms the transmembrane bridge between the cytoskeleton
Stanislava Merjava et al.
Investigative ophthalmology & visual science, 52(2), 787-794 (2010-10-12)
The purpose of this study was to investigate the expression of cytokeratin (CK) 8 in the corneoconjunctival epithelium. In 17 cadaveric corneoscleral discs and 3 other discs, the presence of CK8 alone or CK8, together with CK3, CK15, vimentin, and
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American journal of physiology. Gastrointestinal and liver physiology, 313(3), G180-G191 (2017-06-03)
Esophageal injury is a risk factor for diseases such as Barrett's esophagus (BE) and esophageal adenocarcinoma. To improve understanding of signaling pathways associated with both normal and abnormal repair, animal models are needed. Traditional rodent models of esophageal repair are
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International journal of molecular medicine, 27(5), 701-706 (2011-02-25)
Although recent studies have demonstrated the in vitro hepatic differentiation potential of mesenchymal stem cells (MSCs), the evidence supporting the in vivo engraftment of MSCs, hepatic differentiation and improvement of hepatic function is still lacking. We investigated in vivo hepatic

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